Introduction:

Momordica charantia L. is widely used for consumption and traditional medicine due to its biological activities. Nevertheless, little is known about the effects of bitter melon on healthy cells. Hence, we aimed to evaluate the effects of Momordica charantia extract in human isolated lymphocytes, especially on inflammatory, cytotoxicity, genotoxicity, and mutagenicity aspects.

Method:

For this, we prepared a hydroethanolic extract with fruits and seeds and proceeded with phytochemical identification and quantification. The human purified lymphocytes were exposed to 12.5, 25, and 50 µg/mL of Momordica charantia extract for 24h and, after this period.

Results:

The data showed that the Momordica charantia extract did not induce cytotoxicity, micronucleus frequency alterations, or interleukin-6, interleukin-10 cyclooxygenase-2 activity and the production of nitric oxide; however, it caused DNA damage and a decrease of TNF-α under the experimental conditions and cells applied.

Conclusions:

Our data propose an anti-inflammatory process generated by Momordica charantia mediated by TNF-α reduction.

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