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Journal of Negative and No Positive Results
On-line version ISSN 2529-850X
Abstract
SANTOS-POLEO, Yoselin Dos et al. Elevated D-Dimer and acute pulmonary embolism in COVID-19 patients. JONNPR [online]. 2020, vol.5, n.12, pp.1516-1527. Epub Dec 18, 2023. ISSN 2529-850X. https://dx.doi.org/10.19230/jonnpr.3960.
Introduction.
It has been determined that patients with SARS-CoV-2 infection and severe pneumonia with elevated D-dimer values can develop acute pulmonary thromboembolism (APE) as a complication, being one of the causes related to mortality in this group of patients.
Methods.
A retrospective analysis of 12 patients diagnosed with SARS-CoV-2 infection with high clinical suspicion of APE confirmed by computed tomography pulmonary angiopgraphy (CTPA) was performed and the described findings are described.
Results:
12 patients with diagnosis of severe pneumonia, elevated D-dimer 9.2 μg / ml (1.4 - ˃20 μg / mL) and confirmation of SARS-CoV-2 infection through real-time reverse transcription polymerasa chain reaction (RT-PCR). APEs were observed mainly in segmental arteries (75%) and main arteries (25%).
Pneumonia with patched areas of bilateral ground glass opacities was observed in 100% of the sample as a typical finding of SARS-CoV-2 infection.
Conclusion.
SARS-CoV-2 infection is related to elevation of D-dimer and APE. The CTPA determines the diagnosis, severity and timely management (anticoagulation) of patients with APE. Therefore CTPA should be considered in all patients with elevated D-dimer or clinical worsening.
Keywords : COVID-19; embolism; CT scan; D-dimer; radiology.