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Journal of Negative and No Positive Results

On-line version ISSN 2529-850X

Abstract

SANTOS-POLEO, Yoselin Dos et al. Elevated D-Dimer and acute pulmonary embolism in COVID-19 patients. JONNPR [online]. 2020, vol.5, n.12, pp.1516-1527.  Epub Dec 18, 2023. ISSN 2529-850X.  https://dx.doi.org/10.19230/jonnpr.3960.

Introduction.

It has been determined that patients with SARS-CoV-2 infection and severe pneumonia with elevated D-dimer values can develop acute pulmonary thromboembolism (APE) as a complication, being one of the causes related to mortality in this group of patients.

Methods.

A retrospective analysis of 12 patients diagnosed with SARS-CoV-2 infection with high clinical suspicion of APE confirmed by computed tomography pulmonary angiopgraphy (CTPA) was performed and the described findings are described.

Results:

12 patients with diagnosis of severe pneumonia, elevated D-dimer 9.2 μg / ml (1.4 - ˃20 μg / mL) and confirmation of SARS-CoV-2 infection through real-time reverse transcription polymerasa chain reaction (RT-PCR). APEs were observed mainly in segmental arteries (75%) and main arteries (25%).

Pneumonia with patched areas of bilateral ground glass opacities was observed in 100% of the sample as a typical finding of SARS-CoV-2 infection.

Conclusion.

SARS-CoV-2 infection is related to elevation of D-dimer and APE. The CTPA determines the diagnosis, severity and timely management (anticoagulation) of patients with APE. Therefore CTPA should be considered in all patients with elevated D-dimer or clinical worsening.

Keywords : COVID-19; embolism; CT scan; D-dimer; radiology.

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