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Hospital a Domicilio
On-line version ISSN 2530-5115
Abstract
GUZMAN-MARTINEZ, Javier; GONZALEZ-BENEYTO, Verónica; HERNANDEZ-ISASI, Isidro and BAS-VALERO, Rafael López. Digoxin: alternatives to the rest regimen. Hosp. domic. [online]. 2022, vol.6, n.3, pp.141-145. Epub Aug 22, 2022. ISSN 2530-5115. https://dx.doi.org/10.22585/hospdomic.v6i3.161.
Introduction:
Digoxin is characterized by narrow therapeutic margin which makes its dosing difficult and monitoring of its serum levels necessary. This becomes more complex in patients with chronic nephropathy who require a greater dose adjustment.
Development of the experience:
We present the case of an 88-year-old woman admitted to our unit under treatment with oral digoxin for chronic heart failure with a regimen of 1 tablet daily with rest at weekends, who presented poor symptom control and subtherapeutic serum digoxin levels in controls. Changing the formulation to pediatric oral syrup (Lanacordin® 0.05mg/mL) resulted in better drug levels and symptom control.
Conclusions:
The use of digoxin in oral syrup may be an alternative to tablet formulation, especially in patients in whom drug level control may be complex due to their comorbidities.
Keywords : Digoxin; renal failure; heart failure; chronicity.