Abstract

LOPEZ-LABADY, J.; VILLARROEL-DORREGO, M.  and  BASCONES MARTINEZ, A.. Unusual pigmentation of palate associated to imatinib: a case report. Av Odontoestomatol [online]. 2013, vol.29, n.6, pp.309-314. ISSN 2340-3152.

There are several factors related to oral mucosa pigmentations, among them; some drugs may be able to induce melanin production in oral epithelia. Recently, it has been demonstrated that imatinib metylate (Glivec^®), used to stop tumor growth, may cause oral pigmentation especially on the hard palate. A case is reported regarding a 56 year old female under imatinib treated since 8 years for chronic myeloid leukemia. Oral evaluation showed a diffuse blue/grey hyperpigmentation covering completely hard palate. Histopathologycal analysis revealed melanin accumulation in corion. Patient is under clinical surveillance, with no clinical changes. In order to establish the association between imatinib and oral pigmentation is necessary to discard other factors that may induce melanin production.

Keywords : Imatinib mesylate; oral pigmentation; palatal mucosa.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )