Abstract

DOMINGO GORRICHO, M.  and  VALDIZAN USON, J.R.. QEEG mapping and methadone. Eur. J. Psychiat. [online]. 2008, vol.22, n.1, pp.29-37. ISSN 0213-6163.

Background and Objectives: The aim of the study was to characterise methadone effects on human brain activity in opiate dependence subjects enrolled in a methadone maintenance program (MMP) for at least six months and steady in their diary oral dose for at least one month. Methods: Resting QEEG activity was evaluated in fifteen MMP subjects for the delta, theta, alpha and beta frequency band. Each subject participated in two similar sessions of QEEG recording. The interval between sessions were three hours. Results: Changes in brain activity were shown by QEEG-mapping. MMP subjects showed a decrease in alpha activity and an increase in slow activity. The first QEEG recording showed theta activity and the second displayed delta and theta activity. Conclusions: Results suggest cognitive dysfunction in MMP subjects.

Keywords : Methadone Maintenance Program; QEEG; Slow activity; Opiate dependence.

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