My SciELO
Services on Demand
Journal
Article
Indicators
Cited by SciELO
Access statistics
Related links
Cited by Google
Similars in SciELO
Similars in Google
Share
Archivos de la Sociedad Española de Oftalmología
Print version ISSN 0365-6691
Abstract
ASENSIO-SANCHEZ, V.M.; GOMEZ-RAMIREZ, V. and MORALES-GOMEZ, I.. Erythropoietin concentrations in the vitreous body from patients with proliferative diabetic retinopathy. Arch Soc Esp Oftalmol [online]. 2008, vol.83, n.3, pp.169-172. ISSN 0365-6691.
Objective: To measure erythropoietin (Epo) levels in the vitreous body from patients with proliferative diabetic retinopathy (PDR). Patients and methods: Undiluted vitreous samples were obtained from 44 patients who had not undergone prior vitreous or intraocular surgery. Patients were divided into two groups: A (n= 24) patients with PDR and B (n= 20) patients with retinal detachment, preretinal macular membranes and macular holes. Epo was determined using radioimmunoassay. Results: Epo vitreous concentration in group A was 512 mU/mL (range 120-880) and in group B was 25.1 mU/mL (range 5.2-201) (p< 0.001). Conclusions: These results show that the concentration of Epo in the vitreous body was significantly higher in patients with PDR than in the control group.
Keywords : Diabetes; hypoxia; neuroprotection; angiogenesis; erythropoietin; proliferative diabetic retinopathy.