Abstract

WU, L.  and  EVANS, T.. Immediate changes in intraocular pressure after an intravitreal injection of 2.5mg of bevacizumab. Arch Soc Esp Oftalmol [online]. 2010, vol.85, n.11, pp.364-369. ISSN 0365-6691.

Purpose: To report the immediate changes of intraocular (IOP) pressure after an intravitreal injection of 2.5mg (0.1ml) of bevacizumab. Methods: Prospective, non-controlled, interventional case series of 45 patients undergoing intravitreal injection of 2.5mg (0.1mL) of bevacizumab for a variety of retinal disorders. IOP was measured with a Goldmann tonometer at baseline, immediately after, 30minutes and one day after injection in all of the cases. The main outcome measured was the IOP immediately after injection. Results: At baseline the mean IOP was 16.6±2.8mm Hg (range, 10-24mm Hg; median, 16mm Hg; 25^th percentile, 14mm Hg and 75^th percentile, 18mm Hg). IOP rose to 53.9±18.2mm Hg (range, 16-78mm Hg, median, 54mm Hg; 25^th percentile, 40mm Hg and 75^th percentile, 70mm Hg; p<0.001) immediately after the injection. After 30minutes, the IOP normalized but was still higher than baseline with a mean of 19.8±5.2mm Hg (range, 10-36mm Hg; median,18mm Hg; 25^th percentile,16mm Hg and 75^th percentile, 24mm Hg; P<.01). At 24hours the IOP was 15.7±3.1mm Hg (range,10-24mm Hg; median, 16mm Hg; 25^th percentile,14mm Hg and 75^th percentile,18mm Hg; p>0.05). Conclusions: An intravitreal injection of 2.5mg (0.1ml) of bevacizumab causes a transient elevation of IOP that tends to return to normal 30 minutes later.

Keywords : Intravitreal bevacizumab; Intraocular pressure.

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