Abstract

LOPEZ ALMARAZ, R. et al. Estudio de la enfermedad mínima residual en el cáncer infantil. Oncología (Barc.) [online]. 2004, vol.27, n.10, pp.17-26. ISSN 0378-4835.

The study of minimal residual disease (MRD) in different childhood cancers has acquired a great importance in the last years for the detection and following up of patients with a high risk of relapse and the consequent long term poor prognosis. There are different techniques for MRD detection and quantification, depending on the tumor type: flow cytometry, immunocytology and biomolecular procedures -as fluorescence in situ hybridization (FISH) and reverse transcriptase-polymerase chain reaction (RTPCR)-. This work reviews the different techniques used to identify the MRD during and after treatment of childhood acute leukemia, neuroblastoma, rhabdomyosarcoma and Ewing's sarcoma, and their usefulness as prognostic factors.

Keywords : Minimal residual disease; Flow cytometry; Immunocytometry; RTPCR; Childhood cancer; Acute leukemia; Neuroblastoma; Rhabdomyosarcoma; Ewing's sarcoma (pNET).

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