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Farmacia Hospitalaria
On-line version ISSN 2171-8695Print version ISSN 1130-6343
Abstract
RICOTE-LOBERA, I. et al. Thermolabile drugs: pharmacist intervention as a guarantee of cold chain maintenance. Farm Hosp. [online]. 2014, vol.38, n.3, pp.211-215. ISSN 2171-8695. https://dx.doi.org/10.7399/FH.2014.38.3.1123.
Objective: To determine whether pharmacist is able to guarantee cold chain maintenance of thermolabile drugs during transport using the available information in the reception process and to compare these results with those obtained in a subsequent intervention phase, in which the manufacturing laboratories were contacted. Methods: Intervention study, prospective and comparative "before-after". It was analyzed the storage conditions during transport of all thermolabile drugs received in a 400-bed hospital for 3 months, excluding those from clinical trials. Results: The intervention allowed to ensure cold chain maintenance in 76,5% (n = 488) of received drugs, representing an increase of 41,8% (IC 95% 36,7-46,6%; p < 0,001) compared with the percentage obtained before the intervention. Conclusions: The pharmacist isn't able to ensure the cold chain maintenance of received thermolabile drugs without temperature monitoring device (64,6%). Reports requested from laboratories allowed to increase significantly that percentage.
Keywords : Cold chain; Thermolabile drugs; Drug stability; Drug distribution; Refrigeration; Pharmacist intervention; Protocol; Quality.