Abstract

ALCANTARA MONTERO, A.  and  GONZALEZ CURADO, A.. Desvenlafaxine utility in chronic pain. Rev. Soc. Esp. Dolor [online]. 2016, vol.23, n.5, pp.256-259. ISSN 1134-8046.

Although evidence of desvenlafaxine in neuropathic pain is scarce, it presents some interesting pharmacokinetic properties, as it is not substrate or have activity on P-glycoprotein, and have a metabolism which practically does not depend on cytochrome P450 system, which limits the risk of pharmacokinetic interactions and potential problems associated tolerability when administered with drugs that are CYP2D6 moderate or potent inhibitors or other substrates of this isoenzyme. These characteristics make desvenlafaxine a different antidepressant especially useful in some subgroups of patients with chronic pain (as polypharmacy and patients with liver failure), where comorbid depression is frequent.

Keywords : Desvenlafaxine; chronic pain; neuropathic pain; diabetic polyneuropathy.

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