Abstract

VERA-SIRERA, Beatriz; DELHOM-VALERO, José; BAQUERO RUIZ DE LA HERMOSA, Mª Carmen  and  VERA-SEMPERE, Francisco. Eosinophilic ulcer tongue: a diagnostic challenge controversial pathogenesis. Rev Esp Cirug Oral y Maxilofac [online]. 2013, vol.35, n.3, pp.128-132. ISSN 2173-9161.  https://dx.doi.org/10.1016/j.maxilo.2011.10.005.

Eosinophilic ulcer, also know as traumatic ulcerative granuloma with stromal eosinophilia, is a rare and benign ulcerative lesion of oral mucosa that has a persistent progression, often requiring a differential clinical diagnosis. The diagnosis is only established from histopathological studies, which frequently show morphological features that may be suggestive of a lymphoproliferative process, resulting in a controversial pathogenesis that is still not clarified today. We report the clinical and pathological observations of an eosinophilic ulcer affecting a woman 76 year-old woman. A biopsy was performed twice on a 2.5 cm diameter ulcer affecting the lingual edge. After a clinical follow-up of 5 months, a self-limiting course with the production of a scar was verified. She has currently been scheduled for an extended 24-month clinical follow-up. The morphological and immunohistochemical features found in the biopsy study are presented, and the pathogenesis hypothesis of this uncommon ulcerative lesion is discussed.

Keywords : Eosinophilic ulcer; Traumatic ulcerative granuloma with stromal eosinophilia; Histopathology; Immunohistochemistry.

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