SciELO - Scientific Electronic Library Online

 
vol.16 número1Malformación de Chiari tipo I: evolución postoperatoria a dos años. Análisis de 10 casosConsumo de cocaína como desencadenante de hemorragia en un oligoastrociloma índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados

Revista

Articulo

Indicadores

Links relacionados

  • En proceso de indezaciónCitado por Google
  • No hay articulos similaresSimilares en SciELO
  • En proceso de indezaciónSimilares en Google

Compartir


Neurocirugía

versión impresa ISSN 1130-1473

Resumen

BOTO, G.R.; GOMEZ, P.A.; CRUZ, J. De la  y  LOBATO, R.D.. Overview of the recent clinical trials in severe head injury and analysis of their therapeutic failure. Neurocirugía [online]. 2005, vol.16, n.1, pp.39-49. ISSN 1130-1473.

During the past "Decade of the Brain" several neuroprotective agents have been tested in phase III clinical trials for severe head injury (SHI) but unfortunately none of them significantly improved the outcome of these patients. In contrast to the success achieved by these drugs in animal laboratory studies, the results in terms of neuroprotection in the clinical setting have been disappointing. This paper has been divided in three parts: in the first one, we summarize the pathophysiological mechanisms related to SHI, targeted by the neuroprotective agents. In the second part we review the main clinical trials carried out for SHI to date, and in the third one, we analyze the possible reasons that explain why these agents have failed to show efficacy.

Palabras clave : Clinical trials; Severe head injury; Neuroprotection.

        · resumen en Español     · texto en Español     · Español ( pdf )

 

Creative Commons License Todo el contenido de esta revista, excepto dónde está identificado, está bajo una Licencia Creative Commons