Objective:

Detect in detail the activities which the exposure is greater due to failure in the use of the hazardous drugs or self-protection measures and assess their reduction after carrying out a training session.

Methods:

Prospective and observational study in a general hospital of specialties. For two months to take place by direct observation, an analysis of handling and repackaging of hazardous oral drugs by a technical staff. This time was divided in two stages, taking a training session to pharmacy staff as a turning point, which explained the new system work, protocols developed, it was reported on the management of individual protection equipment and documentation was delivered. Later, the unsafe handling were categorised according the reference documentation: NIOSH and INSHT.

Results:

The total number of observation was 181; 68 for the first time, which 11 (16,2%) accounted for the repackaging of hazardous oral drugs. In all cases there was a unsafe handling. 113 observations in the second period, which 16 (14,1%) were repackaging of hazardous oral drugs. The probability of error was 81,3%. In all cases, the highest probability of error was associated with the use of personal protective equipment.

Conclusions:

Using the direct observation method, the sub-processes have been identified where it is necessary to reduce the risk associated with the management of these drugs, which have been partially reduced after the use of a formative session.

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