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Revista Española de Nutrición Humana y Dietética
versión On-line ISSN 2174-5145versión impresa ISSN 2173-1292
Resumen
SILVA OCHOA, Alfonso Daniel et al. Drug abuse and serum nutritional biomarkers: a retrospective cohort study. Rev Esp Nutr Hum Diet [online]. 2021, vol.25, n.2, pp.227-236. Epub 17-Ene-2022. ISSN 2174-5145. https://dx.doi.org/10.14306/renhyd.25.2.1157.
Introduction
Drug abuse is a public health problem around the globe. Its implications in human health are harmful, compromising nutritional status. It has been shown that malnutrition is moderately prevalent in drug addicts, and a nutritional prescription is significantly beneficial for these patients. Available literature suggests altered blood serum biochemical data in drug addicts. Our study focused on blood serum nutritional biomarkers in drug addicts who did not have a nutritional assessment or treatment. This study aimed to analyze nutritional blood serum biomarkers in subjects diagnosed with drug addiction from January 2010 to June 2020.
Material and Methods
The research was a retrospective cohort, analytical, observational, and was based on a convenience sample. Data about blood serum AST, ALT, fasting glucose, urea, creatinine, total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, and hemoglobin were analyzed from a database of 103 subjects diagnosed with mental and behavioral disorders due to the use of drugs and other psychoactive substances (ICD-10: F10-F19) in the Institute of Neurosciences (INC). Consumed drugs were alcohol, cocaine, amphetamines, MDNA, opioids, marijuana, and psychotropic drugs.
Results
The medians of hemoglobin, total cholesterol, HDL, and creatinine statistically differed between genders and age groups. There were more cases of low blood hemoglobin and hyperglycemia levels in men, (20.4%, and 8.7%, respectively) than women (4.9%, and 0%, respectively). There were low levels of fasting glucose in 8.8% of our sample. Serum creatinine levels were significantly increased in subjects aged 30 or more.
Conclusions
In our sample, there were statistically different medians of hemoglobin, total cholesterol, HDL, and creatinine among groups of gender and age in drug addicts. All medians were within the normal range.
Palabras clave : Substance-Related Disorders; Alcoholism; Marijuana Abuse; Amphetamine-Related Disorders; Opioid-Related Disorders; Cocaine-Related Disorders; Transaminases; Erythrocyte Indices; Creatinine; Drug abuse.