Mi SciELO
Servicios Personalizados
Revista
Articulo
Indicadores
- Citado por SciELO
- Accesos
Links relacionados
- Citado por Google
- Similares en SciELO
- Similares en Google
Compartir
Revista de la OFIL
versión On-line ISSN 1699-714Xversión impresa ISSN 1131-9429
Resumen
BAEZ-GUTIERREZ, N; RODRIGUEZ-RAMALLO, H; IGLESIAS-JEREZ, R y ALVAREZ-DEL VAYO, Benito C. Carboplatin Area Under the Curve dosing in pediatric patients: influence of glomerular filtration rate measurement. Rev. OFIL·ILAPHAR [online]. 2022, vol.32, n.2, pp.179-181. Epub 13-Feb-2023. ISSN 1699-714X. https://dx.doi.org/10.4321/s1699-714x2022000200010.
Introduction:
Carboplatin dosage methods are often based on renal clearance. An accurate determination of the glomerular filtration rate (GFR) can be obtained by measuring 51Cr-EDTA clearance; however, this method is laborious. For that matter, various formulae have been developed to estimate the GFR. The aim of this study is to compare carboplatin doses calculated by Mann/Pein formula with GFR measured by 51Cr-EDTA clearance and GFR estimated with Schwartz formulae in children.
Methods:
All cancer paediatric patients whose GFR was measured by 51Cr-EDTA were included. GFR was also estimated with Schwartz formulae. To calculate carboplatin dose, Mann/Pein formula was used. A target Area Under the Curve (AUC) of 5 mg/ml/min was chosen. Carboplatin doses were calculated with two different values of GFR calculated previously.
Results:
A total of 33 patients were identified with a median age of 10 years old (range 1-17), 63.6% were males. The median weight, height and BSA were 28 kg (range 8-84.4 kg), 137 cm (range 64-182 cm) and 1.04 m2 (range 0,37-2,1 m2) respectively. The mean of carboplatin doses calculated with GFR measured by 51Cr-EDTA was 274.3±135.7 mg and with GFR estimated with Schwartz formulae was 364.9±156.6 mg. The mean difference between methods was 90.6 mg, P<0.001.
Conclusion:
Carboplatin doses calculated with GFR estimated by Schwartz were statistically higher than those measured with 51Cr-EDTA. This variability may be a risk factor leading to inadequate dosage of patients treated with carboplatin.
Palabras clave : Area under the curve; carboplatin; glomerular filtration rate.