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Sanidad Militar
versión impresa ISSN 1887-8571
Resumen
RODRIGUEZ CAGIAO, G. New advances in local anesthetics and their applications in military dentistry: phentolamine Mesylate. Sanid. Mil. [online]. 2019, vol.75, n.2, pp.87-93. ISSN 1887-8571. https://dx.doi.org/10.4321/s1887-85712019000100005.
Objective:
Describing the mechanism of action of the Phentolamine Mesylate (PM), which is not a so well known product in Spain, capable of reversing the effect of local anesthetics used in dentistry, highlighting its indications and analizing its effectiveness and safety.
Data sources:
A literature review has been carried out in the main medical databases as well as in generic search engines.
Selection of studies:
Clinical studies have been selected, carried out since its approval as a medicine for use in the dental field, which have been tested in the countries where it is marketed with the same formula as in Spain.
Data collection:
Data was obtained on the average time of reduction of the anesthetic effect and on the incidence of adverse reactions.
Data synthesis:
All studies show an efficacy and presence of similar adverse reactions, related to the administration of PM and of a placebo, regardless of the way in which the study was conducted.
Discussion:
The use of the PM in the daily practice, should be a decision that must be taken by the professional based on the scientific evidence and the cost-benefit of its administration, having to select which patients are susceptible to its administration.
Conclusions:
PM is an effective and safe medicine in the reduction of the anesthetic effect and with indications both in the field of civil and as in military dentistry.
Palabras clave : Phentolamine Mesylate; Local anesthesia; Dentistry; Military; Efficacy; Adverse reactions; Therapeutic uses.