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Farmacia Hospitalaria
versión On-line ISSN 2171-8695versión impresa ISSN 1130-6343
Resumen
GONZALEZ MUNGUIA, Silvia et al. Etanercept on steroid-refractary acute graft-versus-host disease. Farm Hosp. [online]. 2015, vol.39, n.3, pp.147-151. ISSN 2171-8695. https://dx.doi.org/10.7399/fh.2015.39.3.8000.
Objetive: To describe etanercept use and effectiveness on steroid-refractary acute graft-versus-host disease after hematopoietic cell transplantation. Method: Patients treated with etanercept as off label use for steroid-refractary acute graft-versus-host disease were selected and each patient's medical history was reviewed to assess the clinical response. Results: The study included five patients: four presented with digestive manifestations and one presented pulmonary and liver manifestations. 80% of patients showed a clinical response: 60% a partial response and 20% a total response. In four cases etanercept 25mg was administered twice a week with variable duration of treatment, achieving no response in 1 case (3 weeks), partial response in two 2 cases (4 weeks and 8 weeks) and a complete response in 1 case (8 week period). Only one case was treated with etanercept 50mg administered twice a week for 5 weeks with a partial treatment response. Conclusions: The clinical response rate is consistent with the previously published data. This updates the scarce bibliographic information about etanecept use in steroid-refractary acute graft-versus-host disease. Due to clinical design limitations and the small patient population, future clinical studies should be conducted to assess the efficacy and security of etanercept in these patients.
Palabras clave : Etanercept; Graft-versus-host; Steroid-refractary; Hematopoietic cell; Transplantation.