SciELO - Scientific Electronic Library Online

 
vol.40 número2Influencia de la dieta en el riesgo de infección y de gravedad de la COVID-19: una revisión sistemática índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados

Revista

Articulo

Indicadores

Links relacionados

  • En proceso de indezaciónCitado por Google
  • No hay articulos similaresSimilares en SciELO
  • En proceso de indezaciónSimilares en Google

Compartir


Nutrición Hospitalaria

versión On-line ISSN 1699-5198versión impresa ISSN 0212-1611

Resumen

MACHO-GONZALEZ, Adrián; MARTINEZ-SESMERO, José Manuel  y  SANCHEZ-MUNIZ, Francisco J. Autophagy, a relevant process for metabolic health and type-2 diabetes. Nutr. Hosp. [online]. 2023, vol.40, n.2, pp.457-464.  Epub 05-Jun-2023. ISSN 1699-5198.  https://dx.doi.org/10.20960/nh.04555.

Autophagy is a very active process that plays an important role in cell and organ differentiation and remodelling, being a crucial system to guarantee health. This physiological process is activated in starvation and inhibited in the presence of nutrients. This short review comments on the three types of autophagy: macroautophagy, microautophagy, and chaperone-mediated autophagy, as well as different aspects that control autophagy and its relationship with health and degenerative diseases. As autophagy is highly dependent on functional autophagy (ATG) proteins integrating the phagophore, the role of some key ATG genes and epigenes are briefly commented on. The manuscript deepens discussing some central aspects of type-2 diabetes mellitus (T2DM) and their relationship with the cell cleaning process and mitochondria homeostasis maintenance, as well as the mechanisms through which antidiabetic drugs affect autophagy. Well-designed studies are needed to elucidate whether autophagy plays a casual or causal role in T2DM.

Palabras clave : Autophagy; Types; ATG genes; Degenerative diseases; Type-2 diabetes; Antidiabetic drugs.

        · resumen en Español     · texto en Inglés     · Inglés ( pdf )