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Revista Española de Enfermedades Digestivas
versión impresa ISSN 1130-0108
Resumen
PENA, Joaquín de-la et al. Experimental study of hybrid-knife endoscopic submucosal dissection (ESD) versus standard ESD in a Western country. Rev. esp. enferm. dig. [online]. 2014, vol.106, n.2, pp.98-102. ISSN 1130-0108. https://dx.doi.org/10.4321/S1130-01082014000200005.
Background: Endoscopic submucosal dissection (ESD) is an effective but time-consuming treatment for early neoplasia that requires a high level of expertise. Objective: The objective of this study was to assess the efficacy and learning curve of gastric ESD with a hybrid knife with high-pressure water jet and to compare with standard ESD. Material and methods: We performed a prospective non-survival animal study comparing hybrid-knife and standard gastric ESD. Variables recorded were: Number of en-bloc ESD, number of ESD with all marks included (R0), size of specimens, time and speed of dissection and adverse events. Ten endoscopists performed a total of 50 gastric ESD (30 hybrid-knife and 20 standard). Results: Forty-six (92%) ESD were en-bloc and 25 (50%) R0 (hybrid-knife: n = 13, 44%; standard: n = 16, 80%; p = 0.04). Hybrid-knife ESD was faster than standard (time: 44.6 ± 21.4 minutes vs. 68.7 ± 33.5 minutes; p = 0.009 and velocity: 20.8 ± 9.2 mm2/min vs. 14.3 ± 9.3 mm2/min (p = 0.079). Adverse events were not different. There was no change in speed with any of two techniques (hybrid-knife: From 20.33 ± 15.68 to 28.18 ± 20.07 mm2/min; p = 0.615 and standard: From 6.4 ± 0.3 to 19.48 ± 19.21 mm2/min; p = 0.607). The learning curve showed a significant improvement in R0 rate in the hybrid-knife group (from 30% to 100%). Conclusion: despite the initial performance of hybrid-knife ESD is worse than standard ESD, the learning curve with hybrid-knife ESD is short and is associated with a rapid improvement. The introduction of new tools to facilitate ESD should be implemented with caution in order to avoid a negative impact on the results.
Palabras clave : Endoscopic submucosal dissection; ESD; Hybrid-knife ESD; Water-jet assisted ESD; Experimental endoscopy.
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