Mi SciELO
Servicios Personalizados
Revista
Articulo
Indicadores
- Citado por SciELO
- Accesos
Links relacionados
- Citado por Google
- Similares en SciELO
- Similares en Google
Compartir
Nutrición Hospitalaria
versión On-line ISSN 1699-5198versión impresa ISSN 0212-1611
Resumen
DUAN, Hongyan et al. Association between nutritional status and platelet-to-lymphocyte ratio in patients with hepatocellular carcinoma undergoing transcatheter arterial chemoembolization. Nutr. Hosp. [online]. 2023, vol.40, n.5, pp.1009-1016. Epub 05-Feb-2024. ISSN 1699-5198. https://dx.doi.org/10.20960/nh.04447.
Introduction:
nutritional status and platelet-to-lymphocyte ratio (PLR) have been found to be associated with prognosis in patients with hepatocellular carcinoma (HCC) undergoing transcatheter arterial chemoembolization (TACE).
Objectives:
to evaluate the association between nutritional status and PLR in patients with HCC undergoing TACE.
Methods:
a total of 152 HCC patients received TACE were enrolled. The nutritional status was evaluated by Patient-Generated Subjective Global Assessment (PG-SGA). Patients with PG-SGA A and PG-SGA (B or C) were classified as the well-nourished and malnourished groups.
Results:
according to the PG-SGA, 130 (85.5 %) patients were malnourished. The median PLR was significantly different between well-nourished and malnourished groups (p = 0.008). A positive correlation was found between PLR and PG-SGA score (r = -0.265, p = 0.001). The optimal PLR cutoff value was 102.165 to predict malnutrition, with a sensitivity of 65.4 %, specificity of 72.7 %, and an area under the curve (AUC) of 0.677 (95 % confidence interval (CI): 0.550-0.804; p = 0.008). A logistic stepwise regression model showed that the PLR was associated with nutritional status in Model 1 without adjustment, as well as if adjusted by age, sex, type of TACE (c-TACE/DEB-TACE) and Child–Pugh stage (odds ratio, 0.190; 95 % CI: 0.062-0.582; p = 0.004).
Conclusions:
nutritional status measured by PG-SGA was significantly associated with PLR in patients with HCC undergoing TACE.
Palabras clave : Hepatocellular carcinoma; Transcatheter arterial chemoembolization; Nutritional status; Platelet-to-lymphocyte ratio; Inflammation.