Introduction
Lower respiratory tract infections (LRTIs) are defined as diseases of the lower airways, and include pneumonia and bronchiolitis1. These types of infections represent a substantial and growing cause for public health concern even further in the current context of the COVID-19 pandemic. LRTIs remained the fourth leading cause of years of life lost worldwide, causing 1,515 age-standardised years of life lost per 100,000 people and 2,558,600 deaths in 20172. Globally, deaths from LRTIs decreased by 36.4 % between 2007 and 2017 for children younger than 5 years, while a 33.6 % increase occurred among older adults (≥70 years)2.
Morbidity and mortality associated with LRTIs differ among countries depending on the socio-economic situation, health conditions, nutritional status, and access to health care and resources, among others1. Understanding and quantifying trends in LRTIs in our setting is crucial to enable individualized measures and interventions to be developed that can reduce the LRTI burden, and to identify people at a higher risk of suffering complications. Some studies have been carried out to analyze community- and hospital-acquired pneumonia data from Spain3-7. However, to date the morbi-mortality of overall LRTIs in Spain has not been reported.
The objectives of the study were to determine the incidence of hospitalizations due to LRTIs over time, and to analyze the clinical outcomes of the hospitalized patients according to patients´ characteristics, and also differentiating by the main clinical diagnosis.
Methods
An observational descriptive study was conducted to analyze hospitalizations in acute care hospitals in Spain from 1997 to 2018 (both inclusive). All the data for the study were extracted from the national information system for hospital data in Spain [Conjunto Mínimo Básico de Datos-Hospitalización (CMBD-H) and Registro de Atención Especializada (RAE-CMBD)], which includes aggregated and anonymized data from both public and private hospitals8. The database was established in 1997, is freely accessible and is managed by the Health Information General Sub-Directorate of the Spanish Ministry of Health, Consumer Affairs and Social Welfare. In 2017 the database included information from 96 % of all the acute care hospitals in Spain8. Data for the study were extracted in November 2019 and updated in February 2021.
The study focused on hospitalizations in acute care hospitals in which LRTIs (pneumonia and acute bronchitis/bronchiolitis) were registered as the primary diagnosis. The primary diagnosis refers to the diagnosis established by the attending physician as the main cause of hospitalization. Hospitalizations in which LRTIs were recorded as secondary diagnoses were not included in the study since they refer to clinical events that occur during the patient's hospital stay, and therefore do not constitute the cause of hospitalization.
Diagnoses are registered at hospital discharge and codified according to the Ninth and Tenth Revisions of the International Classification of Diseases (ICD-9 and ICD-10)9,10. The ICD-9 and ICD-10 codes for LRTIs included in this study are shown in Appendix 1.
Collected data included hospitalizations due to LRTIs of any type (also differentiating by the specific diagnosis: pneumonia and acute bronchitis/bronchiolitis), attending medical service (data available for the period 2005-2018), sex and age distribution of the hospitalized patients (<1 year-old, 1-14, 15-44, 45-64, 65-74, >74 years), length of hospital stay (days), and type of hospital discharge (home, exitus, transfer to another hospital, transfer to a residential centre, voluntary discharge, other or unknown).
The number of hospitalizations from all causes during the study period was extracted to determine the proportion of hospitalizations due to LRTIs out of total hospitalizations, and was not used for any other purposes.
The annual incidence rate of hospitalizations, which referred to the number of hospital discharges per 10,000 inhabitants and year, and the annual proportion of hospitalizations due to LRTIs with respect to hospitalization from all causes in the period 1997-2018 were estimated. Length of hospital stay and type of hospital discharge, specifically mortality, were analyzed. Time-trend distribution of the included variables was described. Data were also analyzed according to the primary diagnosis (pneumonia vs. acute bronchitis/bronchiolitis), patients´ characteristics and attending medical service.
Secondly, data for hospitalizations due to LRTIs registered as a primary diagnosis (included in the study) and for hospitalizations with LRTIs recorded either as a primary or secondary diagnosis for the same time-period were compared to analyze the risk of bias.
Data were analyzed using STATA version 13.0. Normality of variables was analyzed using Shapiro-Wilk test. Categorical variables were expressed using absolute and relative frequency, and continuous variables were expressed using median and interquartile range (IQR). Variables were compared between the different diagnoses (pneumonia vs. acute bronchitis/bronchiolitis), sex and age range using Chi-square for categorical data and Mann-Whitney U test for continuous variables.
Results
A total of 85,459,228 hospitalizations from all causes were reported from 1997 to 2018, with a median of 4,122,869 (IQR: 3,343,711 - 4,352,746) hospitalizations per year. Hospitalizations due to LRTIs during the same time period were 2,952,336 (70.6 % pneumonia, 29.4 % acute bronchitis/bronchiolitis), with a median of 142,383 (IQR: 112,667-152,242) hospitalizations per year. The median annual proportion of hospitalizations due to LRTIs was 3.5 % (IQR: 3.4-3.5 %) of total hospitalizations from all causes. The annual proportion of hospitalizations due to pneumonia was significantly higher than for hospitalizations due to acute bronchitis/acute bronchiolitis (median: 2.4 %; IQR: 2.4-2.5 % vs. 1.0 %; IQR: 1.0-1.1; p < 0.001).
The temporal trend of the annual incidence rate of hospitalizations due to LRTIs is shown in Table 1 and Figure 1. Overall, there was an upward trend from 1997. The annual incidence rate increased by 65.7 % in 2018 as compared to 1997 (from 21.3 per 10,000 inhabitants and year in 1997 to 35.3 per 10,000 inhabitants and year in 2018). The lowest rate was in 1997 (21.3 per 10,000 inhabitants), whereas the highest rate was in 2015 (37.03 per 10,000 inhabitants and year). In this year, the incidence seems higher than expected when compared to near years.
When the entire study period is considered, the median annual incidence rate of hospitalizations due to LRTIs was 31.2 (IQR: 27.8-33.0) per 10,000 inhabitants and year (Table 1). It was significantly higher for hospitalizations due to pneumonia than for hospitalizations due to acute bronchitis/ bronchiolitis (22.2; IQR: 19.1-23.5 per 10,000 inhabitants and year vs. 9.0; IQR: 8.4-9.6 per 10,000 inhabitants and year; p < 0.001).
Variables | 1997-1998 | 1999-2000 | 2001-2002 | 2003-2004 | 2005-2006 | 2007-2008 | 2009-2010 | 2011-2012 | 2013-2014 | 2015-2016 | 2017-2018 | Total |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Incidence*, median (IQR) | 22.7 | 26.5 | 26.6 | 28.1 | 30.5 | 31.9 | 32.0 | 32.8 | 32.1 | 34.9 | 35.0 | 31.2 |
(21.3-24.1) | (25.2-27.8) | (26.0-27.3) | (27.8-28.4) | (29.0-32.1) | (31.2-32.6) | (30.9-33.1) | (32.7-33.0) | (31.1-33.1) | (32.9-37.0) | (34.7-35.3) | (27.8-33.0) | |
Main cause of hospitalization a | ||||||||||||
LRTIs of any type, n. | 180,107 | 212,681 | 218,501 | 238,421 | 266,855 | 288,767 | 294,652 | 303,183 | 298,617 | 324,496 | 326,056 | 2,952,336 |
Pneumonia, % | 70.7 | 70.1 | 70.1 | 69.9 | 70.3 | 71.7 | 72.0 | 71.4 | 70.9 | 69.9 | 69.5 | 70.6 |
Acute bronchitis/ bronchiolitis, % | 29.3 | 29.9 | 29.9 | 30.1 | 29.7 | 28.3 | 28.0 | 28.6 | 29.1 | 30.1 | 30.5 | 29.4 |
Sex b, % | ||||||||||||
Male | 59.9 | 59.3 | 60.1 | 59.3 | 58.7 | 57.8 | 57.4 | 56.8 | 56.3 | 54.7 | 53.1 | 57.3 |
Female | 40.1 | 40.6 | 39.9 | 40.7 | 41.3 | 42.2 | 42.6 | 43.1 | 43.7 | 45.3 | 46.9 | 42.7 |
Age, years, % | ||||||||||||
<1 | 15.7 | 14.4 | 16.0 | 15.2 | 14.1 | 12.9 | 12.7 | 13.0 | 11.7 | 12.2 | 12.0 | 13.4 |
1-14 | 16.5 | 13.2 | 14.6 | 13.2 | 13.7 | 13.1 | 13.6 | 11.8 | 10.9 | 10.3 | 10.1 | 12.5 |
15-44 | 8.5 | 7.8 | 8.1 | 7.5 | 7.2 | 7.5 | 7.5 | 5.7 | 5.4 | 5.1 | 5.1 | 6.7 |
45-64 | 12.4 | 12.6 | 11.6 | 11.6 | 11.6 | 12.2 | 12.0 | 11.4 | 12.0 | 11.6 | 12.1 | 11.9 |
65-74 | 16.9 | 18.0 | 16.3 | 16.1 | 15.0 | 13.8 | 12.8 | 12.4 | 13.0 | 12.9 | 13.1 | 14.3 |
>74 | 29.9 | 34.1 | 33.4 | 36.5 | 38.5 | 40.5 | 41.4 | 45.6 | 47.1 | 47.9 | 47.6 | 41.2 |
Attending medical service, % | ||||||||||||
Internal Medicine | NR | NR | NR | NR | 35.0 | 41.8 | 44.1 | 45.5 | 47.3 | 47.5 | 48.2 | 44.5 |
Paediatrics | NR | NR | NR | NR | 23.0 | 24.6 | 25.6 | 23.9 | 21.9 | 21.8 | 21.5 | 23.1 |
Pneumology | NR | NR | NR | NR | 15.3 | 15.7 | 16.4 | 15.9 | 16.8 | 16.0 | 15.2 | 15.9 |
Geriatrics | NR | NR | NR | NR | 1.6 | 1.3 | 2.1 | 2.3 | 2.7 | 3.0 | 3.1 | 2.4 |
Medical Oncology | NR | NR | NR | NR | 1.2 | 1.4 | 1.5 | 1.7 | 1.8 | 1.6 | 1.8 | 1.6 |
Clinical Haematology | NR | NR | NR | NR | 1.0 | 1.1 | 1.1 | 1.1 | 1.1 | 1.1 | 1.1 | 1.1 |
Infectious Diseases | NR | NR | NR | NR | 0.8 | 0.9 | 1.1 | 1.2 | 1.1 | 1.2 | 1.2 | 1.1 |
Anaesthesia, Resuscitation and Intensive Care Services | NR | NR | NR | NR | 0.9 | 0.9 | 0.8 | 0.8 | 0.7 | 0.6 | 0.7 | 0.8 |
Other | NR | NR | NR | NR | 21.2 | 12.4 | 7.3 | 7.5 | 6.5 | 7.3 | 7.4 | 9.7 |
Length of hospital stay, median (IQR) | 9.8 | 9.9 | 9.7 | 9.7 | 9.4 | 8.7 | 8.5 | 8.4 | 8.3 | 8.2 | 8.1 | 8.9 |
(7.8-10.5) | (8.0-11.5) | (8.2-11.3) | (8.1-11.1) | (7.8-10.7) | (8.0-10.7) | (7.5-9.9) | (7.3-9.2) | (7.8-9.1) | (7.1-8.8) | (6.5-9.2) | (7.6-10.4) | |
Mortality, n (%) | 11,736 | 15,455 | 15,454 | 17,369 | 18,989 | 18,759 | 19,244 | 21,487 | 20,066 | 21,698 | 21,257 | 201,514 |
(6.5) | (7.3) | (7.1) | (7.3) | (7.1) | (6.5) | (6.5) | (7.1) | (6.7) | (6.7) | (6.5) | (6.8) |
*: /10,000 inhabitants; IQR: interquartile range; a: p < 0.001 for the comparison between pneumonia and acute bronchitis/bronchiolitis; b: p < 0.001 for the comparison between males and females; NR: not reported.
Men accounted for a higher number of hospitalizations due to LRTIs than women (57.3 vs. 42.7 %; p < 0.001). Around half of the hospitalizations due to LRTIs occurred in people over 74 years of age (41.2 %). Internal Medicine was the attending medical service in most cases, followed by Paediatrics and Pneumology (Table 1).
Table 2 describes hospitalizations, distinguishing between those caused by pneumonia and those caused by acute bronchitis/bronchiolitis. Statistically significant differences were found between both clinical situations in sex, age and attending medical service. Most of the hospitalizations due to pneumonia corresponded to people over 74 years of age (47.1 %). In contrast, hospitalizations due to acute bronchitis/bronchiolitis were more frequent in people under one year (40.7 %), followed by people over 74 years (27.1 %).
Variables | Main cause of hospitalization | |||
---|---|---|---|---|
LRTIs of any type | Pneumonia | Acute bronchitis/ bronchiolitis | pa | |
N (%) | 2,952,336 | 2,084,650 | 867,686 | -- |
(100) | (70.6) | (29.4) | ||
Sex, % | ||||
Males | 57.3 | 60.1 | 50.5 | <0.001 |
Females | 42.7 | 39.9 | 49.5 | <0.001 |
Age, years, % | ||||
<1 | 13.4 | 2.0 | 40.7 | <0.001 |
1-14 | 12.5 | 11.4 | 15.3 | <0.001 |
15-44 | 6.7 | 8.2 | 3.0 | <0.001 |
45-64 | 11.9 | 14.4 | 6.0 | <0.001 |
65-74 | 14.3 | 16.9 | 7.9 | <0.001 |
>74 | 41.2 | 47.1 | 27.1 | <0.001 |
Attending medical service (2005-2018)b, % | ||||
Internal Medicine | 44.5 | 51.9 | 26.5 | <0.001 |
Paediatrics | 23.1 | 11.7 | 50.8 | <0.001 |
Pneumology | 15.9 | 19.4 | 7.3 | <0.001 |
Geriatrics | 2.4 | 2.9 | 0.9 | <0.001 |
Medical Oncology | 1.6 | 1.9 | 0.7 | <0.001 |
Clinical Haematology | 1.1 | 1.4 | 0.4 | <0.001 |
Infectious Diseases | 1.1 | 1.4 | 0.3 | <0.001 |
Anaesthesia, Resuscitation and Intensive Care Services | 0.8 | 0.9 | 0.3 | <0.001 |
Other | 9.7 | 8.5 | 12.7 | <0.001 |
a: comparison between hospitalizations due to pneumonia and hospitalizations due to acute bronchitis/bronchiolitis; b: data correspond to hospitalizations for the period 2005-2018: n = 2,102,626 hospitalizations due to LRTIs; 1,488,469 (70.8 %) due to pneumonia and 614,157 (29.2 %) due to acute bronchitis/bronchiolitis.
When analyzing hospitalizations due to LRTIs that were recorded either as a primary or secondary diagnosis, the distribution according to the clinical diagnosis (pneumonia vs. acute bronchitis/bronchiolitis), sex and age matched those corresponding to hospitalizations with LRTIs as primary diagnosis, which contributed to 67.9 % of all hospitalizations (Appendix 2).
The median length of stay declined over time (from 9.8 days; IQR: 7.8-10.5 in 1997-1998 to 8.1 days, IQR: 6.5-9.2 in 2017-2018) (Table 1, Figure 2). The median length of stay in hospitalizations due to LRTIs was 8.9 days (IQR: 7.6-10.4) (Table 1), and was significantly higher for hospitalizations due to pneumonia than for hospitalizations due to acute bronchitis/bronchiolitis (9.5 days; IQR: 8.3-10.6 vs. 5.7 days; IQR: 5.5-6.2; p < 0.001) (Table 3). The median length of stay was higher in the subgroup of hospitalizations associated with Anaesthesia, Resuscitation, and Intensive Care services (13.8 days; IQR: 13.0-14.7).
Variables | Main cause of hospitalization | pa | ||
---|---|---|---|---|
LRTIs of any type | Pneumonia | Acute bronchitis/bronchiolitis | ||
(n = 2,952,336) | (n = 2,084,650) | (n = 867,686) | ||
Length of hospital stay*, median (IQR) | 8.9 (7.6-0.4) | 9.5 (8.3-10.6) | 5.7 (5.5-6.2) | <0.001 |
Type of discharge, % | ||||
Home | 89.1 | 86.8 | 94.7 | <0.001 |
In-hospital mortality | 6.8 | 9.0 | 1.7 | <0.001 |
Transfer to another hospital | 2.0 | 2.0 | 1.9 | <0.001 |
Transfer to a residential centre | 0.9 | 0.9 | 0.8 | <0.001 |
Voluntary discharge | 0.4 | 0.5 | 0.4 | <0.001 |
Others or unknown | 0.8 | 0.8 | 0.7 | <0.001 |
In-hospital mortality, n (%) | 201,514 (6.8) | 186,989 (9.0) | 14,525 (1.7) | <0.001 |
Sex, %: | ||||
Male | 59.2 | 60.5 | 42.4 | <0.001 |
Female | 40.8 | 39.5 | 57.6 | <0.001 |
Age, %: | ||||
≤74 years | 24.5 | 25.0 | 18.5 | <0.001 |
>74 years | 75.5 | 75.0 | 81.5 | <0.001 |
Attending medical service (2005-2018)b, %: | ||||
Anaesthesia, Resuscitation and Intensive Care Services | 7.9 | -- | -- | -- |
Geriatrics | 5.7 | -- | -- | -- |
Clinical Haematology | 1.9 | -- | -- | -- |
Infectious Diseases | 0.5 | -- | -- | -- |
Internal Medicine | 61.8 | -- | -- | -- |
Pneumology | 8.7 | -- | -- | -- |
Medical Oncology | 4.2 | -- | -- | -- |
Paediatrics | 0.2 | -- | -- | -- |
Other | 9.0 | -- | -- | -- |
*: days; a: comparison between hospitalizations due to pneumonia and hospitalizations due to acute bronchitis/bronchiolitis; b: data correspond to hospitalizations due to LRTIs that ended in death during the period 2005-2018 (n = 141,500).
Data related to the type of hospital discharge are presented in Table 3. In 89.1 % of total hospitalizations due to LRTIs, patients returned home after being hospitalized due to LRTIs. In-hospital mortality was 6.8 % (n = 201,514), with a median of 9,380 deaths per year (IQR: 8,192-10,157). Mortality was significantly higher in hospitalizations due to pneumonia (9.0 vs. 1.7 %; p < 0.001). Between 2005 and 2018, 69.2 % of the hospitalizations associated with Anaesthesia, Resuscitation, and Intensive Care services ended in death (n = 11,189 out of 16,175).
A 75.5 % of the in-hospital deaths occurred in people over 74 years of age. In this age range, 12.5 % of the patients hospitalized due to LRTIs died. Mortality among children under 5 years of age was 0.09 % (635 out of 676,324), and was significantly higher for children under one year of age (Appendix 3). Most of the deaths in children under 5 years corresponded to pneumonia cases (57.2 % pneumonia vs. 42.8 % acute bronchitis/bronchiolitis) and mortality rate was significantly higher for pneumonia than for acute bronchitis/bronchiolitis (0.17 vs. 0.06 %; p < 0.001).
Deaths during hospitalizations due to LRTIs doubled from 1997 to 2018 (from 5,257 deaths in 1997 to 10,514 in 2018) (Figura 3). However, the proportion of hospitalizations due to LRTIs that ended in death out of total hospitalizations due to LRTIs remained stable (between 6.5-7.3 %) (Table 1).
Discussion
We analyzed hospitalizations due to LRTIs in Spain from 1997 to 2018. On average, more than 142,000 hospitalizations due to LRTIs were registered annually and around 9,300 ended in death every year. These data reflect the huge magnitude of this growing problem, which takes on even greater significance globally with the expansion of the SARS-CoV-2 outbreak.
Overall, 71 % of all the hospitalizations due to LRTIs registered during the study period corresponded to pneumonia diagnoses. The pneumonia cases that were acquired during the hospital stay and those who did not require hospital admission should also be added to this figure, since these were not considered in the study. In this regard, both community- and hospital-acquired pneumonia are associated with high morbidity and mortality.
Two reviews that analyzed the burden of community-acquired pneumonia in European adults found that the incidence was higher in individuals aged 65 years or over11,12. Similarly, in our study around 40 % of the hospitalizations due to pneumonia occurred in people over 74 years of age.
We found an increasing trend in the number of deaths amongst people hospitalized for LRTIs. These data are in line with the information from The Institute for Health Metrics and Evaluation (IHME), which describes an increase in the deaths related to LRTIs in Spain from 1997 to 2018 (from 23.92 deaths per 100,000 people in 1990 to 29.96 deaths per 100,000 people in 2018)13.
In our study, around 76 % of the deaths occurred in people over 74 years of age. These data coincide with the results of a review that reported that mortality attributable to community-acquired pneumonia in Europe was associated with advanced age11. The Global Burden of Disease Study 2016 (GBD 2016), which analyzed data regarding LRTIs in 195 countries from 1990-2016, found a high mortality rate in the elderly, with an increase in the number of LRTI deaths among adults of at least 70 years from 2000 to 20161. The study obtained an incidence of 267.4 deaths per 100,000 people older than 70 years (95 % uncertainty interval: 233.4-289.6) in 20161. In Spain, according to data from IHME, deaths in people of at least 70 years reached 195.97 per 100,000 people (95 % uncertainty interval: 160.73-222.35) in 201813.
LRTIs also have major consequences for people at an early age. In our study, mortality among children under 5 years of age hospitalized due to LRTIs was 0.09 % and children under one year were more often affected. Similarly, the GBD 2016 study identified that LRTIs caused 13.1 % (95 % uncertainty interval: 11.8-14.3) of all deaths in children under 5 years of age, most of them occurring in the first year of life1. According to our study, although hospitalizations due to acute bronchitis/bronchiolitis were more frequent than pneumonia amongst children under 5 years, mortality was higher with the latter (0.17 vs. 0.06 %).
We found that the length of hospital stay for hospitalizations due to LRTIs was around 9 days, and was longer for pneumonia and for hospitalizations associated with the Anaesthesia, Resuscitation, and Intensive Care Services. People attended by these medical services are more severely ill, and therefore respiratory infections are associated with a high mortality rate, ranging from 15 to 50 % in the case of pneumonia14. In our study, 69.2 % of the hospitalizations associated with the Anaesthesia, Resuscitation, and Intensive Care services ended in death according to 2005-2018 data. As a result of the devastating clinical consequences of this setting, a number of evidence based guidelines and recommendations have been published in recent years to prevent and manage hospital-acquired and ventilator-associated pneumonia15-18. In addition, several initiatives consisting of multifaceted interventions have been carried out in Intensive Care Units (ICUs) worldwide to tackle the burden of ventilator-associated pneumonia, which showed a positive impact19-21.
In Spain, the Pneumonia Zero project was initiated in 2011, which consisted of a nationwide multimodal intervention to prevent ventilator-associated pneumonia in critically ill patients22,23. The project was carried out from 2011 to 2012 and included 181 ICUs in Spain (75 % of all ICUs in Spain). The adjusted incidence density rate of ventilator-associated pneumonia decreased from 9.83 to 4.34 per 1,000 ventilator days after 19-21 months of intervention23.
Our study has some limitations that should be taken into consideration. The national information system for hospital data in Spain progressively incorporated nationwide information, and so information related to hospitalizations in acute care hospitals may be underreported, especially at the beginning of the study period. This issue may have led to an underestimation of the real extent of LRTIs. In addition, only hospitalizations in which LRTIs were established as the main cause of the hospital admission (primary diagnosis) were included in the study. Cases in which LRTIs were not considered as the main cause of the hospitalization were not analyzed. However, a secondary analysis carried out did not show relevant differences when considering hospitalizations with LRTIs registered either as primary or secondary diagnosis. Apart from this, the change in the ICD system that took place in 2016 may have affected the consistency with previous data. Nevertheless, from 2016 onwards hospitalizations continued to show the upward trend seen in previous years. The database used for the study does not include information about the patients´ socioeconomic status or comorbidities, as it was not possible to study their influence on clinical outcomes.
This study is the first to our knowledge to describe the temporal trend of LRTIs in Spain during 22 years, including both pneumonia and acute bronchitis/bronchiolitis. Conditions of the hospitalized patients and the clinical results were analysed, also differentiating by the specific clinical diagnosis leading to the hospitalization. The study revealed that LRTIs are a growing problem in Spain, with important consequences for the patients´ morbi-mortality. It is also important to note that this clinical condition has a greater impact on people at both extremes of the age range, a vulnerable population that needs special protection. The current COVID-19 pandemic has abruptly increased the incidence of hospitalizations and the mortality rate related to respiratory infectious diseases, and our study may constitute the baseline on which to compare the situation in forthcoming years.
In conclusion, LRTIs have a relevant impact on both morbidity and mortality in Spain. There is an upward trend in hospitalizations and deaths related to LRTIs over time, being both higher for pneumonia than for acute bronchitis/bronchiolitis. Hospitalizations due to pneumonia occurred mainly in people over 74 years and hospitalizations due to acute bronchitis/bronchiolitis in children under one year. Mortality predominantly affected people over 74 years of age. Intensification of measures and specific interventions are needed to reduce the burden of LRTIs, particularly for people at higher risk of suffering complications.