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Hospital a Domicilio
versión On-line ISSN 2530-5115
Resumen
GUZMAN-MARTINEZ, Javier; GONZALEZ-BENEYTO, Verónica; HERNANDEZ-ISASI, Isidro y BAS-VALERO, Rafael López. Digoxin: alternatives to the rest regimen. Hosp. domic. [online]. 2022, vol.6, n.3, pp.141-145. Epub 22-Ago-2022. ISSN 2530-5115. https://dx.doi.org/10.22585/hospdomic.v6i3.161.
Introduction:
Digoxin is characterized by narrow therapeutic margin which makes its dosing difficult and monitoring of its serum levels necessary. This becomes more complex in patients with chronic nephropathy who require a greater dose adjustment.
Development of the experience:
We present the case of an 88-year-old woman admitted to our unit under treatment with oral digoxin for chronic heart failure with a regimen of 1 tablet daily with rest at weekends, who presented poor symptom control and subtherapeutic serum digoxin levels in controls. Changing the formulation to pediatric oral syrup (Lanacordin® 0.05mg/mL) resulted in better drug levels and symptom control.
Conclusions:
The use of digoxin in oral syrup may be an alternative to tablet formulation, especially in patients in whom drug level control may be complex due to their comorbidities.
Palabras clave : Digoxin; renal failure; heart failure; chronicity.