Resumo

VALDIVIA URIA, José Gabriel et al. Research study on renal targeted chemotherapy with magnetic hapoons and intravenous administration of ferro-carbon nanoparticles. Arch. Esp. Urol. [online]. 2007, vol.60, n.1, pp.5-14. ISSN 0004-0614.

Objectives: The use of nanoparticules for drug transport is one of the topics with priority interest within the field of biomedical research. Our objective is to show the initial results of an innovative method to focalize drug carrier ferro-carbon nanoparticules to solid organs. We obtained and characterized various types of ferrous magnetic nanoparticules and studied their behaviour in vitro and in vivo in laboratory animals with intrarenal magnetic targets laparoscopically implanted. Methods: Using a plasma arch we obtained ferro-carbon nanoparticules with the ability to absorb and deliver doxorubicin, showing an excellent behaviour in in vitro rheological studies. Under general anesthesia and control we inserted a gold covered magnetic microharpoon in the left kidney of New Zealand rabbits. At the same time we injected intravenously different doses of various types of nanoparticules. The animals were sacrified after pre-established times and pathologic studies of their kidneys, spleens, livers, lungs and bone marrow were carried out. Results: After selection of the most adequate nanoparticules for our purposes, we ascertained significant differences in the distribution of nanoparticules in post-mortem studies, with accumulation in the magnetic target and surrounding renal parenchyma. Nevertheless, the reticuloendothelial system retains a great amount of the injected dose. Conclusions: Although our magnetic focalization system is effective, nanoparticule temporary protection systems should be tested to allow us avoid the action of the immune system.

Palavras-chave : Renal carcinoma; Drug carriers; Drug delivery; Magnetic implant; Magnetic nanoparticules; Nanomedicine.

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