Meu SciELO
Serviços Personalizados
Journal
Artigo
Indicadores
Citado por SciELO
Acessos
Links relacionados
Citado por Google
Similares em SciELO
Similares em Google
Compartilhar
Anales de Medicina Interna
versão impressa ISSN 0212-7199
Resumo
BLANCO, J.R. et al. Determination of antibodies against A-60 antigen for diagnosis of M. tuberculosis infection: An useful tool for rationalizing of chemoprophylaxis in HIV patients. An. Med. Interna (Madrid) [online]. 2001, vol.18, n.3, pp.23-27. ISSN 0212-7199.
Objective: To identify M. tuberculosis infection in HIV patients by use of PPD and an ELISA test detecting the presence of antibodies against antigen A-60 of M. bovis. Methods: 116 incoming HIV patients were classified according to the CDC. The status of M. tuberculosis infection was probed with PPD (RT-23) and the state of anergy was estimated by a Multitest CMI (Multitext®). The presence of circulating antibodies of the IgG class against antigen A-60 was analysed by an ELISA. The clinical course of the patients was followed for 24 month. Results: A positive serology (A-60) was found in 52.58% of the patients, coinciding with 70.45% of the positive PPD (p<0.003). This statical observation was found when we studied all of the individuals, and those with more than 500 CD4 lymphocytes. The Multitext® was positive in 11.11% of the patients with PPD (-), all of them without antibodies against A-60. However, 42.2% of the aptients who were PPD and Multitext® (-), had circulating antibodies against A-60. The following up of the patients during 24 months allowed the detection of 7 news cases of pulmonary tuberculosis, 4 of them had a positive A-60 serology, and 4 were anergy. Conclusions: HIV patients with M. tuberculosis infection have circulating antibodies against A-60 antigen of M. bovis with independence of their immunity status. In anergic patients the presence of this antibodies can be an useful tool for rationalizing the prophylaxis against M. tuberculosis. A seropositivity (A-60) indicates as well as does PPD a previous contact with M. tuberculosis.
Palavras-chave : A-60 antigen; HIV; Tuberculosis; M. tuberculosis infection; Anergy.