Resumo

GARCIA LARA, N.R.  e  FRIAS GARCIA, M.E.. Preventive therapy in migraine disorders: when and how. Rev Pediatr Aten Primaria [online]. 2010, vol.12, n.45, pp.123-138. ISSN 1139-7632.

Authors´ conclusion: despite the fact that several drugs to prevent migraines have been studied in children, most trials have small size and poor design. Flunarizine and propranolol are the best studied drugs although the clinical evidence is not consistent enough. In relation to topiramate, its effectiveness has to be confirmed in more adequately designed studies. Reviewers´ commentary: topiramate and flunarizine show acceptable evidence reducing frequency and intensity of migraines in children. Propranolol has controversial evidence, so it is advisable to keep it for second choice. All three drugs are safe. There is an urgent need to perform well designed and large trials to establish solid evidence with topiramate, flunarizine and propranolol.

Palavras-chave : Migraine disorders; Prevention and control; Child; Adolescent.

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