Background:

Human immunodeficiency virus (HIV) in patients have increased their life expectancy, making HIV a chronic illness, thanks to the antiretroviral treatment (ART), which, despite the fact it is not able to eradicate the HIV, it keeps the viral load supressed and increases the number of CD4 lymphocytes. Consequently, the number of comorbidities in this population has increased so, its polypharmacy as well.

Objective:

To analyze the ART and nonART medication of HIV patients ≥50 years old, determining the degree of polypharmacy and relevant interactions.

Material and methods:

Observational retrospective study, mono-site, analytical and transversal. HIV patients ≥50 years old who went to the Pharmacy Service for collecting medication from January 7th untill February 3rd, 2019. The following variables were selected: age, sex, stratification according to the Strategy of Pharmaceutical Care to the Patient Chronic of Jimena®, ART and non-ART medication.

Results:

A total of 114 patients ≥50 years old were included, 96.97% had concomitant medication, highlighting drugsfor the cardiovascular system and for the central nervous system. 99 significant interactions ART/non-ART were identified in 66 patients, occurring mainly with drugs for the central nervous system. The ARTs mainly involved were the nonnucleoside reverse transcriptase inhibitors, boosted protease inhibitors and boosted integrase inhibitors (INI).Conclusions: Prescribe physicians of ARTs must take into account to the polypharmacy of the patients, try to deprescribe unnecessary medication as much as possible and find alternatives with less repercussion, such as the use of Inhibitors of the Integrase, in the context of ART

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