SciELO - Scientific Electronic Library Online

 
vol.33 número2Vitamina C, tiamina e hidrocortisona: ¿aliados en shock séptico?Evaluación del focus group con farmacéuticos realizado en el proyecto “Igualdad y no discriminación en la atención farmacéutica a personas transexuales en de un libro blanco “España. Elaboración de un libro blanco” índice de autoresíndice de assuntospesquisa de artigos
Home Pagelista alfabética de periódicos  

Serviços Personalizados

Journal

Artigo

Indicadores

Links relacionados

  • Em processo de indexaçãoCitado por Google
  • Não possue artigos similaresSimilares em SciELO
  • Em processo de indexaçãoSimilares em Google

Compartilhar


Revista de la OFIL

versão On-line ISSN 1699-714Xversão impressa ISSN 1131-9429

Resumo

OTERINO-MOREIRA, I et al. Incidence of adverse drug reactions in COVID-19 hospitalised patients through the minimum basic data set. Rev. OFIL·ILAPHAR [online]. 2023, vol.33, n.2, pp.161-168.  Epub 04-Mar-2024. ISSN 1699-714X.  https://dx.doi.org/10.4321/s1699-714x2023000200011.

Background:

At the beginning of the COVID-19 pandemic many drugs were used with an uncertain benefit/risk profile that needed to be evaluated. The goal of this study was to analyse the incidence of adverse drug reactions (ADRs) and describe the drugs used in COVID-19 hospitalised patients at the beginning of the COVID-19 pandemic through the minimum basic data set (MBDS).

Methods:

Retrospective observational study that included hospitalised patients with COVID-19 at our centre between March and May 2020 who had ADRs coded in discharge/death medical reports according to the International Classification of Diseases (ICD-10). Those patients with ADRs ascribed to COVID therapy were selected and the causal relationship was evaluated using the Naranjo algorithm. Descriptive statistical analysis was used.

Results:

We identified 141 ADRs in 110 cases of hospitalisation due to COVID-19 that entailed an incidence of 9.66% (141/1459), CI95% 8.25-11.29. From the ADRs analysed, 60.3% (85/141) were ascribed to COVID therapy. Lopinavir/ritonavir represented 38.8% (33/85) of ADRs, glucocorticoids 23.5% (20/85) and hydroxychloroquine 9.4% (8/85)

Out of the ADRs, 31.8% (27/85) were gastrointestinal disorders (probable lopinavir/ritonavir), 27.0% (23/85) blood glucose disorders (probable glucocorticoid) and 17.6% (15/85) hypertransaminasaemia (probable azithromycin, possible lopinavir/ritonavir, possible hydroxychloroquine, possible interferon).

Regarding intensity, 64.7% (55/85) were mild cases, 29.4% (25/85) moderate and 5.9% (5/85) severe. The percentage of ADRs that did not require intervention were 24.7% (21/85), 32.9% (28/85) required pharmacological treatment, 40.0% (34/85) suspension of the drug, 1.2% (1/85) close monitoring and 1.2% (1/85) dose reduction.

Conclusions:

The incidence of ADR in COVID population that required admission at the beginning of the pandemic seems to be higher than in the general population. The MBDS proves to be a useful tool to trace ADRs.

Palavras-chave : Minimum basic data set (MBDS); adverse drug reaction (ADR); COVID-19 therapy; Naranjo algorithm; causality relationship.

        · resumo em Espanhol     · texto em Inglês     · Inglês ( pdf )