Aim:

Identify induce severe skin reaction´s drugs that have been reported up to 2020 in Iberoamerican countries, recognizing the associated drugs with each syndrome (SSJ-NET, DRESS and AGEP).

Data selection and methodology:

A retrospective, non-experimental study was performed based on a systematic review of the medical literature related to induce sever skin reation´s drugs available in the databases of PubMed, Scopus, Scielo and Google scholar. The search and data selection were limited on reviewed articles published in Spanish, with no time limit. 27 of 574 clinical cases identified the drugs that induce serious skin reactions, excluding the cases of patients with skin reactions that do not specify whether they are secondary to drugs.

Results:

The findings included the report from the following countries: Argentina, Costa Rica, Guatemala, Mexico, Paraguay, Ecuador, Peru and Spain. The reported drugs that cause server skin reactions, belong to the following therapeutic groups: anticonvulsants, antibacterials, antiretrovirals, minocycline, lamotrigine, gold sales, beta-lactams, macrolides, quinolones, antifungals, calcium channel blockers, protease inhibitors, nonsteroidal anti-inflammatory drugs and acetaminophen; presenting pharmacological interactions, all of them between serious and fatal prognosis.

Conclusions:

When comparing the findings, it was determined that the drugs that cause server skin reactions belong to many diverse therapeutic groups, being the more frequently: anticonvulsants, alopurinol and some antibiotics. No specific tendency was found related on a specific drug reported on the analyzed countries.

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