SciELO - Scientific Electronic Library Online

 
vol.33 número2Revisión bibliográfica sobre la Gestión Integral de la Farmacoterapia en pacientes hospitalizados en Cirugía Ortopédica y TraumatologíaTrombocitopenia asociada a ceftarolina en combinación con daptomicina: a propósito de dos casos índice de autoresíndice de assuntospesquisa de artigos
Home Pagelista alfabética de periódicos  

Serviços Personalizados

Journal

Artigo

Indicadores

Links relacionados

  • Em processo de indexaçãoCitado por Google
  • Não possue artigos similaresSimilares em SciELO
  • Em processo de indexaçãoSimilares em Google

Compartilhar


Revista de la OFIL

versão On-line ISSN 1699-714Xversão impressa ISSN 1131-9429

Resumo

AZNAR-GARCIA, M; CANTO-MANGANA, J  e  MARTINEZ-DE LA PLATA, JE. Atrial fibrillation and QT prolongation after a single dose of hydroxychloroquine. Rev. OFIL·ILAPHAR [online]. 2023, vol.33, n.2, pp.206-208.  Epub 04-Mar-2024. ISSN 1699-714X.  https://dx.doi.org/10.4321/s1699-714x2023000200015.

Non-antiarrhythmic drugs may induce QT-prolongation and increase the risk of arrhythmias. Recent studies have determined that there is a risk of atrial fibrillation (AF) due to QT prolongation. We report a case of FA associated to QT prolongation secondary to a single dose of hydroxychloroquine (HCQ) in an 83-years-old polymedicated patient admitted to our hospital due to SARS-CoV-2 infection. Quetiapine was prescribed as regular medicine after admission and a 5-days oral HCQ regimen was started for COVID-19. Thirty minutes after HCQ loading dose, FA was reported on electrocardiogram (EKG). COVID-19 treatment is leading to use off-label drugs that may generate adverse effects. It should be considered that drugs that induce QT prolongation may be triggers for atrial arrhythmias. There is not any report of sudden onset of increased QT interval with associated arrythmia after a single dose of HCQ, even in a short course treatment.

Palavras-chave : Hydroxychloroquine; prolonged QT interval; COVID-19; atrial fibrillation; adverse drug reactions; drug interactions.

        · resumo em Espanhol     · texto em Inglês     · Inglês ( pdf )