Resumo

RICO CORRAL, M. A. et al. Carnitine deficiency myopathy: a case of late diagnosis. An. Med. Interna (Madrid) [online]. 2002, vol.19, n.8, pp.39-42. ISSN 0212-7199.

Myopathies caused by lipidic metabolism alterations are very infrecuent. Carnitine deficiency-associated myopathies are included in this group. Two main types of carnitine deficiency syndromes have been delineated: a predominantly myopathic form, with normal serum and low muscle carnitine levels, and a systemic form, with encephalopathy, hepatic dysfunction, muscle weakness and low muscle, liver and serum carnitine levels. Both types have typical lipid stores in muscle biopsy. We describe the case of a myopathic form of carnitine deficiency. Due to the age of the patient, this is an unusual case, with an unfavourable evolution. Therapeutic measures used in these patients have included prednisone, carnitine replacement and a low-fat with medium chain tryglycerides and high-carbohydrate diet. However, in none of the patients responding to therapy, a significative increase in muscle carnitine has been demonstrated.

Palavras-chave : Lipidic myopathy; Carnitine; Carnitine-palmityl-transferase.

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