Resumo

GOICOECHEA-GARCIA, C et al. Some preclinical results of cannabinoids and pain. Rev. Soc. Esp. Dolor [online]. 2022, vol.29, suppl.1, pp.3-9.  Epub 28-Nov-2022. ISSN 1134-8046.  https://dx.doi.org/10.20986/resed.2022.4033/2022.

The role of the endocannabinoid system in the modulation of nociception and in the interpretation of those signals in known since the middle of the last century. The work carried out since then has made possible to better understand mechanisms of action involved and to synthesize different drugs able to modulate these signals. These drugs can be agonists, aimed at directly activating cannabinoid receptors, or substances that modulate the enzymes responsible for the synthesis and degradation of endocannabinoids. Pharmacologically, other substances present in the Cannabis sativa plant are also being studied, as well as synthetic derivatives obtained from these, which can bind, in addition to the aforementioned receptors, to other types of receptors involved in the physiology of the nociception. Results obtained to date demonstrate efficacy in multiple animal models of pain, both acute and chronic, both nociceptive and neuropathic, and offer new of research lines for the pharmacological treatment of chronic pain.

Palavras-chave : Cannabinoids; pharmacology; preclinic; rat; mouse.

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