Resumo

MARTINEZ-MARTINEZ, Marco U.; MANDEVILLE, Peter; LLAMAZARES-AZUARA, Lilia  e  ABUD-MENDOZA, Carlos. CKD-EPI is the most reliable equation to estimate renal function in patients with systemic lupus erythematosus. Nefrología (Madr.) [online]. 2013, vol.33, n.1, pp.99-106. ISSN 1989-2284.  https://dx.doi.org/10.3265/Nefrologia.pre2012.Jun.11101.

Background: No study has determined the best equation for estimating renal function in patients with systemic lupus erythematosus (SLE), starting from a gold standard test. Objective: To evaluate the performance of cistatin/creatinine based equations for estimating renal function in patients with SLE. Methods: We conducted two phases: the first phase included 14 patients in which iothalamate clearance was used to determine the glomerular filtration rate (GFR) and compared with different equations based on cystatin C and/or creatinine. In the second phase, we used the best equation (a cystatin and creatinine-based equation) as "reference standard" to compare 5 creatinine-based equations in 55 patients with SLE. Results: In the first phase the equation developed by Stevens and colleagues (based on creatinine and cystatin C), was the best equation. In phase 2, the CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) equation was the best equation with bias of -2.1ml/min/1.73, accuracy (P30) of 94.5% and precision (interquartile range of differences) of -2.1 ml/min/1.73. Conclusions: Our data suggest that CKD-EPI is the best creatinine-based equation to estimate GFR in patients with SLE.

Palavras-chave : Glomerular filtration rate; Systemic erythematosus lupus; Equations.

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