SciELO - Scientific Electronic Library Online

 
vol.39 número2Escala de Fenotipos de Comportamiento Alimentario (EFCA), análisis factorial confirmatorio y propiedades psicométricas¿Puede la terapia de flora intestinal convertirse en un nuevo objetivo para la diabetes mellitus de tipo 2? Revisión basada en 13 ensayos clínicos índice de autoresíndice de assuntospesquisa de artigos
Home Pagelista alfabética de periódicos  

Serviços Personalizados

Journal

Artigo

Indicadores

Links relacionados

  • Em processo de indexaçãoCitado por Google
  • Não possue artigos similaresSimilares em SciELO
  • Em processo de indexaçãoSimilares em Google

Compartilhar


Nutrición Hospitalaria

versão On-line ISSN 1699-5198versão impressa ISSN 0212-1611

Resumo

WANG, Lihua; LIU, Yiran; HU, Feng  e  ZHOU, Zhongyu. The potential mechanisms of white adipose tissue browning: a novel target for the treatment of obesity. Nutr. Hosp. [online]. 2022, vol.39, n.2, pp.411-424.  Epub 09-Maio-2022. ISSN 1699-5198.  https://dx.doi.org/10.20960/nh.03852.

The increase of the obesity pandemic worldwide over the last several decades has generated a constant need for the scientific world to develop new possibilities to combat obesity. Since the discovery that brown adipose tissue (BAT) exists in adult humans, and BAT activation contributes to a negative energy balance, much more attention has been focused on the understanding of the molecular switches and their different regulatory mechanisms turning on energy expenditure. Recent insights have revealed that a range of stimuli including cold exposure, physical activity and diet, and critical transcription molecules such as PPARγ, PRDM16, PGC-1α and UCP1, aiming at the induction of BAT activation, could cause the browning of white adipose tissue, thereby dissipating energy and increasing heat production. An increasing number of studies that point to the white adipose tissue (WAT) browning strategies aiming at diet-induced and/or genetically determined obesity have been tested in mouse models as well as in human studies. Findings suggested that browning stimulating drugs have been currently or previously assayed as a therapy against obesity. As PPARα agonists, fibrate drugs effectively reduced plasma triglyceride, increased high-density lipoproteins, and improved glycemic control and heat production in brown adipose tissue, which has been used in the treatment of metabolic disorders. Many kinds of natural products promote white adipose tissue browning, such as alkaloids, flavonoids, terpenoids, and long-chain fatty acids, which can also ameliorate metabolic disorders including obesity, insulin resistance and diabetes. The aim of this review is to summarize the transcriptional regulators as well as the various mediators that have been regarded as potential therapeutic targets in the process of WAT browning.

Palavras-chave : White adipose tissue; Brown adipose tissue; Browning; Obesity; Energy balance.

        · resumo em Espanhol     · texto em Inglês     · Inglês ( pdf )