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Nutrición Hospitalaria
versão On-line ISSN 1699-5198versão impressa ISSN 0212-1611
Resumo
MENG, Xiang-Tian; SHI, Yun-Yue e ZHOU, Hong-Yan. Dietary omega-3 LCPUFA intake in the prevention of neovascular age-related macular degeneration: a systematic review and meta-analysis. Nutr. Hosp. [online]. 2022, vol.39, n.4, pp.910-915. Epub 31-Out-2022. ISSN 1699-5198. https://dx.doi.org/10.20960/nh.03932.
Purpose:
to evaluate the protective effect of omega-3 long-chain unsaturated fatty acids on the progression of wet age-related macular degeneration (wAMD).
Methods:
this meta-analysis was designed, implemented, and analyzed in accordance with the Meta-analysis of Observational Studies in Epidemiology (MOOSE) protocol and is reported following PRISMA guidelines.
Results:
in this study we included 5 observational trials, including 2 cross-sectional studies, 2 case-control studies, and 1 confrontation study. These tests are conducted in the U.S., Europe and Japan, and are of high quality. In general, people with high dietary long-chain omega-3 polyunsaturated fatty acids (omega-3 LCPUFAs) have a lower risk of progression to advanced age-related macular degeneration (AMD) (effect size, ES: 0.51, 95 % CI [0.34, 0.75], I2 = 70 %, p = 0.01). When assessing docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) intake and wAMD risk a total of the three above studies were included, which also produced similar results.
Conclusions:
the highest DHA consumption reduced the risk of disease by 39 % (effect size: 0.61, 95 % CI [0.50, 0.74], I2 = 14 %, p = 0.31); compared with the lowest EPA consumption, the highest EPA consumption reduced the risk of wAMD by 32 % (ES: 0.68, 95 % CI [0.57, 0.82], I2 = 39 %, p = 0.20).
Palavras-chave : Neovascular age-related macular degeneration; wAMD; Omega-3 LCPUFAs; Dietary fat acid; Docosahexaenoic acid; Eicosapentaenoic acid.