Introduction:

Keratinocytes present in the epithelial cells of the human body produced, continuously, small amounts of histamine that are kept in balance in the oral epithelium. When this balance is disturbed, there is an increase in histamine in the oral tissue and it can cause injuries.

Objective:

In this review work we studied the relationship of excess histamine in Oral Lichen Planus, oral Leukoplakia and Oral Squamous Cell Carcinoma.

Material and Method:

Bibliographic search of the literature of case control and retrospective studies about the role of histamine in Oral Lichen Planus, Oral Leukoplakia and Oral Squamous Cell Carcinoma.

Results:

An increase in the number of mast cells and histamine has been observed in oral tissues with pathology compared to healthy tissues.

Conclusion:

This increase in the number of mast cells and histamine in oral tissues with pathology can cause disorganization in the precursors of inflammation and thus can further damage the oral tissue.

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