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Cirugía Plástica Ibero-Latinoamericana
versão On-line ISSN 1989-2055versão impressa ISSN 0376-7892
Resumo
RUBIO-YANCHUCK, Mónica; TOLEDANO-REAL, Víctor e BONASTRE-JULIA, Jorge. Tolerance induction to endotoxin in a composite tissue transplant. Cir. plást. iberolatinoam. [online]. 2018, vol.44, n.3, pp.251-257. Epub 08-Fev-2021. ISSN 1989-2055. https://dx.doi.org/10.4321/s0376-78922018000300003.
Background and Objetive
Endotoxin tolerance is a biological phenomenon which consists in desensitization of immune system cells to low exposures to lipopolysaccharide (LPS). It leads to antigens anergy.
The aim of this study is to asses the development of tolerance after precondicioning with LPS in the context of a composite tissue transplant.
Methods
Transferences of hind legs were made between rats crossing the Main Histocompatibility Complex (MHC). The animals were divided into 2 groups according to the preconditioning they received, LPS and physiological saline.
Results
The control group presented a median survival of the allograft less tan 15 days after the cessation of inmunosupressive treat-ment. The group preconditioned with LPS presented median survival greater than 30 days (p=0.001).
Conclusions
The mechanism of tolerance to endotoxin increases the survival of composite tissue allotransplantation.
Palavras-chave : Tissue transplantation; Composite tissue transplantation; Transplant survival; Endotoxin.
