Background and objective.

Lipograft provides volumetric rejuvenation that improves the quality of facial tissue by a mechanism that could involve the participation of stem cells.

Our objective is to evaluate the efficacy and safety of lipotransfer by assisted centrifugation with stem cells derived from adipose tissue in facial aging.

Methods.

Double-blind randomized comparative clinical trial (phase III) in 70 patients, 35 who received lipotransfer facial treatment assisted with stem cells (study group) and 35 who received conventional facial lipotransfer by centrifugation (control group).

Results.

Percentage of fat graft volume conservation required over time (control group, p < 0.001; study group, p = 0.223); stem cell-assisted treatment reduced the risk of loss of fat graft preservation by 86%. The patient's wrinkles disappeared and decreased, none remained on the most unfavorable aging scale. The changes occurred in the 2 groups were significant (p < 0.001) with better results in the experimental group. No complications were reported. All patients were satisfied. Regarding the evaluation of the final result, in 94.3% it was good in the study group and in the same proportion of the patients in the control group it was fair.

Conclusions.

In our study lipotransfer by centrifugation assisted with stem cells derived from adipose tissue stands out as being effective and safe in facial rejuvenation, superior to conventional lipotransfer by centrifugation.

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