Resumo

CHIMENOS KUSTNER, Eduardo; FONT COSTA, Imma  e  LOPEZ LOPEZ, José. Oral cancer risk and molecular markers. Med. oral patol. oral cir. bucal (Ed.impr.) [online]. 2004, vol.9, n.5, pp.377-384. ISSN 1698-4447.

The clinical appearance and, especially, the degree of dysplasia that may be shown by pre-cancerous lesions in the oral cavity suggest a potential for malignisation. An increasing number of studies are seeking new, more specific markers that would help to determine the degree of cell alteration and enable a better understanding of the degree of malignant degeneration of these cells. The present review considers the most recent findings for these markers, grouping them into families: tumour growth markers; markers of tumour suppression and anti-tumour response; angiogenesis markers; markers of tumour invasion and metastatic potential; cell surface markers; intracellular markers; markers derived from arachidonic acid; and enzymatic markers.

Palavras-chave : Molecular markers; tissue markers; epithelial dysplasia; oral leukoplakia; oral squamous carcinoma.

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