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Revista de la OFIL
versão On-line ISSN 1699-714Xversão impressa ISSN 1131-9429
Resumo
GUZMAN-RAMOS, MI et al. Real life study of sacubitril valsartan combined therapy in chronic heart failure. Rev. OFIL·ILAPHAR [online]. 2021, vol.31, n.3, pp.317-320. Epub 30-Maio-2022. ISSN 1699-714X. https://dx.doi.org/10.4321/s1699-714x20210003000011.
Objectives:
Sacubitril/valsartan is a drug for chronic heart failure (CHF), approved by Drugs Regulatory Agencies based on the results of the PARADIGM-HF, which could have several limitations on internal validity and applicability. Furthermore, this drug has a high economic impact.
The objectives of this study are to evaluate effectiveness and safety of sacubitril/valsartan in CHF, as well as to evaluate adequation to use criteria stablished in a Health Management Area (HMA).
Methods:
Retrospective, observational study including adult patients with CHF who were receiving sacubitril/valsartan during 2017 in an HMA. The treatment effectiveness was assesed by death and/or hospitalization rates related to CHF. Frequency of adverse events was used to safety evaluation. Furthermore, adequation rate was assessed.
Findings:
A total of 68 patients were included. Death or hospitalization rates due to CHF at 12 months were 32.3% globally (2.9% and 29.4% respectively). Among patients analyzed, 33.8% presented hypotension, during the first year after treatment initiation. Overall adequation rate was 67.6%.
Conclusions:
A high percentage of death and/or hospitalization due to CHF was observed. Hypotension is a frequent adverse event which leads to dose adjustment and/or drug withdrawal. Overall adequation rate of sacubitril/valsartan prescription is acceptable.
Palavras-chave : Chronic heart failure; sacubitril/valsartan; hypertension; pharmacotherapy; real-life study.