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Revista de la Sociedad Española del Dolor
versão impressa ISSN 1134-8046
Resumo
ROCHE BUENO, JC. Efficacy of pregabalin, gabapentin and duloxetine in neuropathic pain verified by the p-curve analysis. Rev. Soc. Esp. Dolor [online]. 2020, vol.27, n.1, pp.16-23. Epub 27-Abr-2020. ISSN 1134-8046. https://dx.doi.org/10.20986/resed.2020.3727/2019.
Introduction:
There is a growing concern among clinicians and researchers that many results published in scientific journals are false positives.
Objective:
To determine the value of evidence or integrity of the body of the published literature on the efficacy of pregabalin, gabapentin and duloxetine in the treatment of neuropathic pain.
Methods:
A literature search was conducted selecting randomized clinical trials that evaluated the efficacy of pregabalin, gabapentin and duloxetine in neuropathic pain. The p-curve analysis of the studies with statistically significant results was applied to study their distribution.
Results:
It was demonstrated that there was a significant asymmetry to the right in the p-curve of the three drugs (continuous test p <0.0001) confirming the value of evidence from the studies.
Conclusions
Clinicians, scientists and scientific publications should be aware of the growing problem with "p-hacking" and its harmful effects. All parties share the responsibility to maintain the scientific integrity of the published literature.
Palavras-chave : P-curve; duloxetine; pregabalin; gabapentin; neuropathic pain; treatment.