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Revista Clínica de Medicina de Familia
versão On-line ISSN 2386-8201versão impressa ISSN 1699-695X
Resumo
MORALES-ESPINOSA, Rosario et al. Patterns of in vitro antimicrobial susceptibility of Gram-negative bacteria isolated from urinary tract infections in outpatients of a clinic in southern Ciudad de México. Rev Clin Med Fam [online]. 2020, vol.13, n.2, pp.131-138. Epub 21-Set-2020. ISSN 2386-8201.
Objectives:
To determine patterns of antimicrobial susceptibility of Gram-negative bacteria isolated from urine cultures of outpatients, and to associate them with variables such as age, sex, previous urinary infection, and presence of type-2 diabetes mellitus.
Material and methods:
Descriptive, observational, cross-sectional study, with strains isolated from 278 patients with low urinary infection, who had outpatient consultation in CMF Dr. Ignacio Chávez of the Instituto de Seguridad y Servicios Sociales de los Trabajadoresdel Estado, in southern Ciudad de México, between March 2018 and February 2019. The Becton-Dickinson Phoenix 100 system was used both for identifying strains, and for determining antimicrobial susceptibility. 16 antimicrobial agents were tested. Descriptive statistics was used for determining resistance proportion. Statistical programme SPSS version 22.
Results:
278 strains were included: 231 Escherichia coli, 24 Klebsiella spp., 8 Enterobacter spp., 7 Proteus spp., 7 Citrobacter spp., 1 Serratia spp. The greatest resistance was for: ampicillin with 74.1% and the greatest sensitivity was for amikacin with 100%. Of all strains, 140 (50.4%) were multidrug resistant, and none was pandrug resistant. When the study variables were associated with resistance to each antimicrobial, there was statistical significance only between cephalosporins cefazolin and cefoxitin, as well as imipenem with patient sex, with higher percentage in men.
Conclusions:
High resistance was obtained in virtually all the groups of antimicrobials. This makes it necessary to be aware of susceptibility patterns in each area or country.
Palavras-chave : Urinary tract infections; Outpatients; Antimicrobial drug resistance; Gram-negative bacteria; Escherichia coli.