Abstract

LEAL-GUTIERREZ, J.  and  JIMENEZ-ROBAYO, L.. Computational analysis of punctual mutations in bovine PRKAG3 gene associated to meat quality. Arch. zootec. [online]. 2014, vol.63, n.241, pp.121-132. ISSN 1885-4494.  https://dx.doi.org/10.4321/S0004-05922014000100012.

PRKAG3 protein is one of the three components of AMPK and it has a regulatory function in this molecule. This gen had been associated with several quality traits of porcine meat. Computational analysis of mutations in exonic region was established using SNP (single nucleotide polymorphism) reported in datebases. The aim was highlight the mutations that can change some physicochemical traits in RNAm and/or protein. Polymorphism 1796C and 2338T in ARNm and 389T in protein of bovine PRKAG3 were the most important because they theoretically can modify the normal working ofthese molecules. Additionally, in-silico, the porcine polymorphism 200Q (RN-, strongly associated to meat quality) modifies several features of RNAm and its protein.

Keywords : AMPK; Muscle glycogen; Electrostatic potential; Isoelectric point.

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