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Archivos Españoles de Urología (Ed. impresa)

Print version ISSN 0004-0614


MAROTO, José Pablo et al. Allogeneic transplantation or peripheral blood hematopoietic stem-cells with low intensity conditioning for the treatment of a metastatic clear cell carcinoma: Preliminary results after two years of follow-up. Arch. Esp. Urol. [online]. 2006, vol.59, n.1, pp.44-48. ISSN 0004-0614.

Objectives: To evaluate the toxicity and outcomes of the allogeneic transplantation of peripheral blood hematopoietic stem-cells with low intensityconditioning (mini-alo Bone Marrow transplantation-BMT) in metastatic renal cell carcinoma refractory to at least one line of systemic treatment. Methods: From 30 patients submitted to the Sant Pau`s Hospital for immunotherapy between 1/2001 and 1/2003, six patients finally underwent mini-alo BMT within a clinical trial. Conditioning: Fludarabine: 30 minute IV infusion of 13 mg/m2 on days - 9, - 8, - 7, - 6 and - 5. Busulfan: 1 mg/kg (real weight) q 6 hours, PO on days - 6, -5, and - 4 (4 doses per day on days - 6 and - 5, and 2 doses only on day - 4, total number of doses 10). Results: Two patients achieved partial response, one patient stabilized disease, and two patients hadprogression on days + 30 and + 60. Therefore, 2/3 patients surviving more than six months achieved partial response. One patient died on day + 30 after acute hepatic graft-versus-host disease. Complete chimerism was demonstrated in all patients. Conclusions: The mimni-alo BMT is feasible inpatients with metastatic renal cell carcinoma and provides objective responses, although its efficacy should beconfirmed by phase III clinical trials.

Keywords : Kidney cancer; Peripheral; Allogeneic cell transplant.

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