Abstract

FERNANDEZ-GARCIA, N. et al. Resultados de las peticiones de anticuerpos tiroideos en un Hospital Provincial de Castilla-León . Rev Diagn Biol [online]. 2001, vol.50, n.4, pp.197-199. ISSN 0034-7973.

Objectives: To evaluate if simultaneous determination of both TPOAb and TgAb is clinically more adequate than single determination of TPOAb.  Materials and methods: quantification using a microplate immunoassay of 1236 samples in which an autoimmune thyroid protocol was requested (TPOAb and TgAb).  Results: Patients were classified by positive or negative results of both TPOAb and TgAb as follows: TPOAb (-) - TgAb (-), 61.4%; TPOAb (+) - TgAb (-), 22.8%; TPOAb (+) - TgAb (+), 13.6% and TPOAb (-) - TgAb (+), 2.2%; a higher prevalence of positive results was observed in women in comparison to men 30% n 6.3% for TPOAb and 13.6%n 2.2% for TgAb.  Conclusions: the simultaneous protocol (TPOAb and TgAb) for thyroid autoimmune diseases have no more clinical usefulness than a single protocol (TPOAb). The first one protocol must be reserved for concrete clinical situations as differentiated thyroid cancer whereas the single one (TPOAb) could be implanted on routine.

Keywords : antithyroid peroxidase antibodies (TPO-Ab); antithyroglobulin antibodies (Tg-Ab); TSH-receptor antibodies (TR-Ab); hyperthyroidism; hypothyroidism.