Abstract

SANCHEZ ZALABARDO, D. et al. Prognosis factors in pT3 renal cell carcinoma. Actas Urol Esp [online]. 2003, vol.27, n.1, pp.26-32. ISSN 0210-4806.

OBJECTIVES: To identify independent predictors of progression and global survival in patients affected by pT3 renal cell carcinoma. To make risk groups by risk factors. MATERIAL AND METHODS: We evaluated 117 patients with pT3 renal cell carcinoma. 88 was M0 and 29 M1. Most frecuent clinical feature: asintomatic patiens. 80 males (69%) and 37 females (31%). Mean age 59 (24-82). Median follow up 34 monthsw (mean 44 ± 39 months). RESULTS: Pathological stage (TNM 1997) was pT3a in 52 patients (43.6%), pT3b 63 patients (53.6%) and pT3c 2 patients. Histology: clear cell carcinoma 106 patients (90.6%), papillary 5 patients (4.3%) an dchromophobe 4 patients (3.4%). Nuclear grading according Fuhrman´s classification: G1 13 patients, G2 45 patients, G3 32 and G4 12 patients. Size > 4 cm (p=0.005 / p=0.0019), grade 3-4 (p=0.006 / p=0.0007), N+ (p=0.034 / p=0.009) and M+ (p=0.035 / p=0.042) were independent prognosis factors for progression and global survival of the pT3 renal cell carcinoma. Patiens M0 with 0 or 1 risk factor have better global survival tanh patiens M0 with 3 or 4 risk factors and patiens M1. CONCLUSIONS: Size, grade, N+ and M+ were independent prognosis factors for progression and global survival of the pT3 renal cell carcinoma. Tera are no differencias in global survival betwen patients M0 with 2 or 3 risk factors and patients M1.

Keywords : Renal cell carcinoma; PT3; Prognosis factors.

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