Abstract

SANCHEZ ZALABARDO, D. et al. Human androgen receptor gene mutations in patients uit clinically localized prostate cancer. Actas Urol Esp [online]. 2004, vol.28, n.3, pp.221-229. ISSN 0210-4806.

The aim of this study was to detect mutations in the human androgen receptor gene in radical prostatectomy specimens. MATERIAL AND METHODS: The genomic sequence was realized in 67 radical prostatectomy specimens. The mean age was 64 years old. The PSA median was 15 ng/ml. TNM 1997: 34.3% were T1 and 65.7% T2. Genomic sequence: 1. Radical prostatectomy specimens desparaffitation. 2. Extraction of the DNA 3. DNA amplification. 4. Automatic genome sequence. 5. Comparison with Gene-Bank. RESULTS: 16.7% of the specimens were mutated. The most frequent mutation was the puntual mutation. The exon most frecuent mutated was exon 1.

Keywords : Prostate cancer; Radical prostatectomy; Androgen receptor; Androgen receptor gene; Genomic sequence.

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