Abstract

TRABA VILLAMEYTIDE, Mª L.  and  FERNANDEZ-GUERRERO, M.. Indinavir and renal lithiasis. Actas Urol Esp [online]. 2004, vol.28, n.7, pp.523-526. ISSN 0210-4806.

Indinavir is a new specific and potent drug that inhibits, like other antiretroviral agents, the protease of immune deficiency virus (HIV) or acquired immune deficiency syndrome (AIDS), an enzyme necessary to maduration and replication of the virus. Indinavir has the capacity to bind the active site causing a decrease in plasma of HIV1-RNA and an increase of T-CD₄ helper lymphocytes. The aim of this work is to study in HIV and/or AIDS patients treated with indinavir the crystalluria and the formation of renal calculi due to the clearance of this drug. Two out of nine patients studied in this work presented abundant crystalluria and one of them presented spontaneously passed renal stone. Urinary crystals were studied under polarized-light microscopy and renal stone was analyzed by infrared spectroscopy.

Keywords : Indinavir; HIV-1; AIDS; Crystalluria; Renal calculi.

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