Abstract

GOMEZ PEREZ, L. et al. Role of chronic prostatic infiltrate from specimens of prostate biopsy in total and free PSA determination. Actas Urol Esp [online]. 2005, vol.29, n.2, pp.170-173. ISSN 0210-4806.

Purpose: To analyze the influence in total serum PSA (PSA_t) and free PSA (PSA_l) of chronic inflammatory patterns from prostate biopsy specimens of non-symptomatic patients. Patients and methods: 518 non-symptomatic patients underwent ultrasonography and prostatic biopsy for PSA_t> 4 ng/mL and/or DRE suspicious of malignancy. Those with a negative biopsy were divided into two subgroups: patients with benign prostatic lesions (LBP) and patients with chronic inflammatory signs (SIC). Results: 456 patients (88.03%) were biopsied for elevated PSAt or/and DRE suspicious of malignancy in 62 patients (11.97%). Mean volume in patients with LBP was 54cc, while 51cc was the mean volume in patients with histological pattern of chronic inflammatory infiltrate. Mean PSA_t in patients with LBP was 9.43 (IC 95% ± 7.8) and 8.8 (IC 95% ± 5.73) in SIC's group patients. Conclusions: The presence of SIC has no significant influence in the eventual value of PSA_l y PSA_t in a selected population. As a result of that finding data from serum PSA can be reliably evaluated even in the presence of SIC in biopsy specimens.

Keywords : Chronic inflammation; PSA; Prostate biopsy.

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