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Actas Urológicas Españolas

Print version ISSN 0210-4806


LLEDO GARCIA, E. et al. Recent avances in the comprehension of the effects of cold ischemia in kidney graft. Actas Urol Esp [online]. 2005, vol.29, n.4, pp.392-400. ISSN 0210-4806.

Cold ischemia is the best known method to preserve kidneys for transplant. However, it produces several detrimental effects. First, cellular necrosis. Secondarily, during the hypothermic period a mithocondrial injury process develops which makes the cell entering a pre-apoptotic state. This apoptosis occurs definitively in the reperfusion. Preservation solutions currently available are not perfect and are not able to avoid cold-related cell injuries. The adition of certain substances to UW solution (desferrioxamine) has shown experimentally a reduction in mitochondrial cold-related lesions. Isolated hypothermic kidney perfusion reduces initial graft dysfunction about 20% in comparison to hypothermic storage. This fact relates to important either economical as functional consequences.

Keywords : Renal Transplant; Cold Ischemia; Renal Preservation.

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