Abstract

ARZOZ FABREGAS, M. et al. Isolated prostatic intraepithelial neoplasia and positive cancer results at repeat biopsy: Our series review. Actas Urol Esp [online]. 2005, vol.29, n.8, pp.735-738. ISSN 0210-4806.

Objetive: To review the incidence of isolated prostatic intraepithelial neoplasia (PIN) as well as the positive prostate cancer results in repeat biopsy in our series of transrectal biopsy of the prostate. We compare these results with the actual literature. Materials and Methods: We review the 2.475 transrectal ultrasound guided biopsies of the prostate made in our department from January 1992 to June 2004 looking for intraepithelial neoplasia and looking in particular for isolated High-grade PIN ( HGPIN). We review repeat biopsies made at this patients and the likelihood of detecting prostate cancer in them. Results: The diagnosis of PIN was found in 31 biopsies, 13 of them were isolated HGPIN what means a 0,52% incidence of the total biopsies performed in our department. We performed 7 repeat biopsies of the 13 cases in a period from 3 months to 2 years after the first biopsy, and we found 3 cases of prostate cancer what means that 43% of isolated HGPIN with repeated biopsy showed prostate cancer. The mean age of the patients studied was 67 years (range 53-88). The median PSA value of the studied cases was 9,8 ng /ml. The Gleason score of the positive biopsies was always between 3 and 7. In our series, age and PSA levels did not have correlation with the positive results for prostate cancer in repeated biopsies. Conclusions: In spite of a lower number of HGPIN cases in our series, the positive for prostate cancer in repeated biopsy ( 43%) is similar to the incidence reported in literature so it is advisable rigorous controls and repeated biopsies for these patients.

Keywords : Prostatic Intraepithelial Neoplasia; Prostate biopsy; Prostate cancer.

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